1. MSc. DOAN Duc Chanh Tin 2. BS. LE Thi Thanh Tuyen 3. Eng. PHAM Xuan Thanh Tung 4. BscE. TRAN Phu Duy
5. BS. PHAM Van Binh
Introduction
Nanobiosensors group develops and produces various nanostructures for sensor technology, including nanowires of various materials, single nanopore membrane, nanoelectrodes, nanogaps, nanoresonators and nanocantilevers etc. All these structures with the dimensions of the active part down to a few nanometers can be used to build up many kinds of smart and powerful nanosensors as reported recently by researchers around the world. Especially, we develop a new fabrication process that utilizes only techniques of conventional microfabrcation technology to fabricate an array of nanowires of various materials at a wafer-scale. In addition, each nanowires from the fabricated array is individually electrically addressed, thus making easily to be connected to outer electronics control for further characterization as well as building up interested nanowire based nanodevices.
Currently, in the frame of the National Key Project (KC.04.12/06-10,) research of the Nanobiosensors has been devoted to made then apply the fabricated nanowires ( Pt and Si) as biosensors for detection of several important biological species like glucose, ADNs, and Proteins. Applications for the developed sensors are ranging in various vital sectors like healthcare, food industry, and environment etc.
Some images
Figure 1: Metal nanowires ( Au, Pt, Pd, mono-crystalline Si) with width of 50 nm, fabricated by using conventional microfabrication techniques
Figure 2: An array of nanowires is made on silicon chips. Each single wire from the array is individually electrically addressed for multiplexed detections of several (biological) species.
Figure 3: Electrical characterization (I-V, in a normal air) of Pt nanowire with thickness of 25 nm, the wire width of 40±5 nm, and wire length of 20 µm.
Conducted Projects
Study on fabrication technology of DNA chip used in biology analysis (Governing organization: VNU - HCM; Length: 03/2005 - 09/2006).
Study on application MEMS technology for fabricating micro array used in biology analysis (Governing organization: LNT; Length: 09/2005 - 06/2006).
Study on fabricating platinum nanowire used for diagnosing glucose’s quantity in blood (Governing organization: VNU - HCM; Length: 09/2005 - 06/2006).
Study on the immobilization of glucose oxidase enzyme on platinum nanowire for detecting glucose (Governing organization: VNU - HCM; Length: 10/2006 - 06/2007).
Study on quantitative analysis glucose using platinum thin film (Governing organization: LNT; Length: 06/2007 - 02/2008).
Study on fabrication of nano bio-sensor for diagnosis and quantitative analysis of some biological compounds (Governing organization: LNT; Length: 07/2007 - 07/2008).
Study on fabrication of nano bio-sensor for diagnosis and quantitative analysis of some biological compounds (Level: National - KC.04/06-10; Length: 01/2008-12/2010).
Publications
1. Microfabrication of microarray on silicon substrate for biological analysis; Mai Thi Anh Dao, Dang Mau Chien, Tong Duy Hien; Proceedings of the 1st IWOFM – 3rd IWONN Conference (ISBN: 987-90-9021459-7), pp. 372-374, Halong, Vietnam; Dec 6-9, 2006. 2. Microfabrication of Silicon Micro Arrays (DNA chips) and its application in research for Immobilization and Hybridization of Oligonucleotides; Nguyen Hoang Phuong Uyen, Mai Thi Anh Dao, Tong Duy Hien, Dang Mau Chien; 15th International Conference on Composites or Nano Engineering, ICCE-15, Haikou, Hainan Island, China; Jul 15-21, 2007 3. Fabrication of wafer-scale platium nanowires and its application in glucose detection; Tong Duy Hien, Tran Nhan Ai, Le Dang Khoa, Le Thi Thanh Tuyen, Dang Mau Chien; 15th International Conference on Composites or Nano Engineering, ICCE-15, Haikou, Hainan Island, China, July 15-21, 2007. Proceeding of 15 4. Investigation of immobilization process of ligonucleotide on microfabricate microarrays; Nguyen Hoang Phuong Uyen, Mai Thi Anh Dao, Tong Duy Hien, Dang Mau Chien; Proceedings of IWNA 2007, Vung Tau, Vietnam; Nov 15-17, 2007. 5. Study on glucose sensing of sputtered Pt electrodes; Tran Nhan Ai, Le Thi Thanh Tuyen, Dang Le Khoa, Tong Duy Hien, Dang Mau Chien; Proceedings of the 1stVietnam, pp. 576-579. International Workshop on Nanotechnology and Application, IWNA 2007. 6. Biosensor based on platinum nanowires for glucose quantitative analysis; Le Thi Thanh Tuyen, Tran Nhan Ai, Tong Duy Hien, Dang Mau Chien; Proceedings of the 1stVietnam, pp. 572-576. International Workshop on Nanotechnology and Application, IWNA 2007. 7. Wafer-scale fabrication of Pt nanowires and its application for glucose detection; Tong Duy Hien, Tran Nhan Ai, Le Thi Thanh Tuyen, Pham Xuan Thanh Tung, Dang Mau Chien; in preparation, to be submitted.
Collaboration Information
1. Nanosens Research B.V , The Netherlands 2. MESA+ Research Institutes for Nanotechnology, The Netherlands 3. Wageningen University, The Netherlands 4. Institutes of Agricultural Genetic, Vietnam 5. Institute of Tropical Biotechnology, Vietnam 6. Cho Ray Hospital, Vietnam.
Technology transfer
Several batches of our fabricated nanowire chips have been made and transferred for our research partners at hospitals and biological research institutes for further application in detections of glucose, ADNs, and proteins, and viruses etc. Beside biological section, which is given our highest priority at this moment, we will soon fabricate nanowire chips of appropriate materials for other applications in various sectors like nanoelectronics, nanomagnetics, and optics etc.
Contact Information
Dr. ir. TONG Duy Hien - Chief of Research & Development Department
Institute for Nanotechnology (INT)
Address: Community 6, Linh Trung Ward, Thu Duc City, Ho Chi Minh City
Tel: 028 3724 6823 / 028 3724 6832 Ext 101 or 102 - Fax: 028 3724 2163
Email: int@vnuhcm.edu.vn
028 37 2468 23 /32
